Thome's clutch homer moved him past Rafael Palmeiro for 11th on the all-time list. Thome also upped his career RBI total to 1,584, which is tied for 36th place on the all-time list with Rogers Hornsby.
Next up on the home run list is Harmon Killebrew with 573.
"For me, it's humbling to talk about," Thome said. "When you get to this stage, it's something. It's pretty surreal to me. I'm just humbled and blessed."
Before Thome's at-bat, he received a huge ovation from the Phillies fans. He even got a nice hand after the homer. Thome remains one of the most popular players ever to play in Philadelphia.
"It was special, very surreal," Thome said. "The people here from day one have treated me just great."
Before the game, Twins manager Ron Gardenhire gushed about the 40-year-old Thome.
"It's fun to get him in the lineup," Gardenhire said. "I love seeing him walk up to the plate. He's a presence and a force. I love writing a future Hall of Famer's name on the lineup card."
Or seeing him rip a home run like that.
"Whenever he needs me, I'm ready," Thome said. "I'm a team guy, and this whole group here is filled with team guys. It's nice to talk about home run records. I'm humbled by that. I'm really excited to talk about winning."
Andy Jasner is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.