Span, who has been dealing with migraines stemming from his concussion suffered on June 3 in a home-plate collision, said before the game that he planned to sit out for precautionary reasons.
But he ended up serving as a pinch-hitter with one out in the ninth inning, and laced a double off reliever Blake Wood before eventually scoring on a walk-off single from Trevor Plouffe that helped the Twins avoid their 100th loss.
"It was a good feeling," Span said. "Before the game started, I said how me coming back and playing the games I had before was the highlight of my season but definitely tonight was. I wasn't expecting to come off the bench, and so to come up and get a big hit like that was very huge for me."
Span played in five games in late September after being shut down for a little more than a month with migraines after he initially returned from his concussion in early August. Span hit .278 (5-for-17) with two triples and two doubles in those five contests, and said it gives him plenty of optimism heading into next year.
"It made my season," Span said. "It meant a lot for me to come back, just to see if I could come back from something of this magnitude. So for me, I couldn't have asked for more."