Hendriks retired the first eight batters he faced until issuing a walk to designated hitter Jeff Mathis in the third. Minnesota's right-hander then eventually saw his no-hitter come to an end in the fourth when Jose Bautista singled up the middle.
That was the only damage Toronto could muster all afternoon against Hendriks, who didn't allow a run while striking out two. Hendriks has now allowed just four earned runs in 20 innings this spring.
"I'm not sure if they're lining me up for Minnesota. I'm not sure if they're lining me up for [Triple-A] Rochester. I just don't know," Hendriks said. "But I try not to think too much about it and just go out there and get all my work done and prove that I'm going to work hard and I'm going to try to get better every outing, and I think I proved that today."
Blue Jays starter Aaron Laffey cruised through four innings but pitched his way into trouble in the fifth. Right fielder Aaron Hicks got things started with a double to left field which was later followed by an RBI triple off the bat of center fielder Ben Revere. Jamey Carroll then capped the two-run inning with a single to left to score Revere and give the Twins a 2-0 lead.
Parmelee opened the sixth with a shot well over the wall in right field for his fourth homer of the Grapefruit League season. Brian Dinkelman and J.R. Towles immediately followed with a pair of hits to chase Laffey from the game.
Laffey, who is competing for the final spot in Toronto's rotation, was charged with four runs on eight hits in five-plus innings. He struck out three and issued his first walk of the spring, while throwing 50 of his 86 pitches for strikes.
Up next: Right-hander Anthony Swarzak is set to make his second Grapefruit League start on Saturday against the Pirates at Hammond Stadium at 12:05 p.m. CT on Gameday Audio. Swarzak, who has a 3.86 ERA this spring, is being stretched out in case Scott Baker and Jason Marquis aren't ready to start the season. Right-hander Kevin Correia starts for Pittsburgh.