Minnesota starter Liam Hendriks was strong until the Rays plated three in the sixth, all charged to him. Hendriks went 5 1/3 innings and allowed four runs on nine hits, walking none and striking out three. Lobaton's homer, a two-run shot to right-center, came with one out in the sixth on the first pitch and put Tampa Bay ahead, 3-2.
"The heat got to me a little bit, and with a couple of long innings of us hitting, it makes it a little bit difficult for me to get back out there and stuff like that," Hendriks said. "I'm not making any excuses. I just left a few pitches up."
Rays starter Jeremy Hellickson was knocked around the last time he pitched at the Twins' spring home, and he rebounded Tuesday with two runs allowed in four innings. Hellickson gave up six hits, walked none and struck out one after he gave up 10 runs in three innings at Hammond Stadium on March 24.
"I felt pretty good," Hellickson said. "I feel a little better every start and I feel like I'm ready for [my first regular-season start] Sunday."
Both of Minnesota's runs came in the fourth inning, when Joe Mauer, Justin Morneau and Josh Willingham doubled in succession to start the frame against Hellickson.
The Rays' Fernando Rodney returned to game action after a line drive caught him on the forearm last week. Rodney pitched a scoreless inning with one baserunner allowed on a walk. Rodney's health is particularly important with closer Kyle Farnsworth's throwing elbow in question.
Tampa Bay finishes spring 10-16-6, while Minnesota finishes 18-15-1.
Up next for the Twins: The Twins play their Class A team, the Fort Myers Miracle, at Hammond Stadium in a 12:05 p.m. CT on Wednesday. Right-hander Nick Blackburn is scheduled to start for the big league club, while 24-year-old righty Marty Popham pitches for Fort Myers.