He went 1-for-4 with a single in the eighth inning while making a few nice plays in the field, including a spin and throw to get Mark Trumbo on a ball hit up the middle in the eighth.
"Everything went good," said Dozier, who picked up his first hit against reliever David Carpenter. "I was real exited. I hit a couple balls hard and made all the plays. We came up with a loss, which was the biggest thing, but I'm excited everything went well."
The 24-year-old hit .276 with a homer, four doubles and two stolen bases in 28 games with Triple-A Rochester before hearing the news on Saturday that he'd be called up.
"It's something everybody dreams about," Dozier said before the game. "It's something I dreamed about for 20-something years now. It was emotional for me when I first got called up, so I've had a couple days to let it all soak in. But it's very overwhelming. I've been very blessed, and so I'm very excited to be here."
Dozier was the club's Minor League Player of the Year last year and ranks as the team's No. 14 prospect, according to MLB.com.
Twins manager Ron Gardenhire met with Dozier before the game and stressed to him that it's important to take it all in, because you only get one big league debut.
"We just want him to go out there and relax and have some fun," Gardenhire said. "It's his first chance to play on a Major League field, and he gets the chance to face [Jered] Weaver, which makes it bigger, so that's cool. So it's a big moment. For those of us who had the opportunity to play in a Major League ballgame, it's an experience you should really take in."
With Dozier at shortstop, Jamey Carroll shifted over to second base, with Alexi Casilla out with a minor shoulder injury sustained on a diving play in Seattle.
Gardenhire also met with Carroll before the game to tell him that he'll be shifting all over the diamond now that Dozier is expected to be the club's starting shortstop moving forward.
"He understood totally," Gardenhire said. "He's done it his whole career. He played great shortstop for us, so I wanted to let him know it wasn't a demotion and not a knock on him. He's been a great shortstop for us, but our best player down there was Mr. Dozier. So we want him to get exposure up here. So Jamey, Alexi, all of them will move around. Even at third base, too."