The right-handed reliever joined the Twins on Friday after having his contract purchased from Triple-A Rochester on Thursday. Minnesota's move came after placing Anthony Swarzak on the disabled list with a mild right rotator cuff strain.
Perdomo last pitched in the Majors in 2010 with the Padres. He posted a 0.92 ERA with 18 strikeouts in 19 2/3 innings for Rochester after the Twins signed him as a Minor League free agent in the offseason.
Expect to see plenty of cutters, manager Ron Gardenhire said.
"You're going to see quick arm action," Gardenhire said of the 28-year-old. "He's going to wing it. He's going to let it fly. He doesn't hold anything back. He's max effort on every pitch ... We'll see how he does."
Perdomo earned a save in his last appearance for the Red Wings, in which he worked 3 2/3 innings on July 25. But the Twins will utilize him in a situational role, not long relief, Gardenhire said.
The 6-0, 170-pounder recorded a 3.60 ERA with five strikeouts in five innings in Spring Training.
"I think it was a good impression," Perdomo said through teammate Alexi Casilla. "Every time I got the opportunity I was trying to do my best, 100 percent. I think that's why I'm here."
"I'm feeling very good to get the opportunity."