Plouffe, who originally jammed his thumb on a swing on July 20, is set to play with the Red Wings on Saturday and Sunday before joining the Twins on Monday if all goes to plan.
"He'll get some swings, make sure the thumb is good and we'll get him back up here," Twins manager Ron Gardenhire said. "He's got to get some live at-bats. BP is fine, he says he feels good, but he's got to face the ball coming in 90 mph and see how it feels coming off the bat.
"You put him out here tonight, he takes a swing, jams himself, we lose 21 days, I'm not going to do that."
Plouffe has been taking swings since Wednesday, and said everything has felt fine, but that it's taken his thumb a while to heal because there was some nerve damage.
"The last couple days I've been able to hit with no pain," Plouffe said. "It's something that won't fully heal until the offseason but it's manageable right now and feels good enough to swing, so that's enough for me."