Nishioka, in his first three games this season, made three errors and went 0-for-12 at the plate. He also let a pop-up drop in front of him in Wednesday's 6-2 loss.
With Nishioka on the bench, Alexi Casilla made the start at second base with Jamey Carroll at third base.
"We're going to play everybody as always," Twins manager Ron Gardenhire said. "We'll see how we go day-to-day. Alexi's going to play. Alexi swung good the other day. Jamey's been picking it over there, so you play the guys you feel give you the best chance to win each night."
Nishioka was roundly criticized for his performance against the Indians, but said that he hopes to learn from his mistakes.
"I think you have to take it all in," Nishioka said through translator Ryo Shinkawa. "Not just the praises you hear from people in the media but you always have to take the tough criticism and try to take that and have it help you improve as a player.
"Just looking back in Japan, there were tough times and I was criticized. So you have to take it all in and hope it helps you grow as a player."