Escobar, one of two players acquired from the White Sox on July 28 for left-hander Francisco Liriano, started at shortstop and hit ninth. He went 2-for-4 with three RBIs and two runs scored in the Twins' 18-9 rout.
"I think he's taken plenty of ground balls out here, so put him out there and let him play," Twins manager Ron Gardenhire said before the game. "I'm excited to see him out there."
Escobar played in 36 games with Chicago before the trade, but Tuesday marked his Twins debut after playing 35 games with Triple-A Rochester. Escobar, 23, admitted he was saddened to be immediately assigned to the Minors after the trade, but is glad to be back.
"I felt a little bit disappointed because I wanted to be here. I was in the big leagues," said Escobar, who hit .217 at Triple-A. "But I understood I had to go back to Triple-A and do the things I do to get back to the big leagues."
He returned to the Majors on Tuesday, facing the team that dealt him away.
"This is a little hard because I played all my career with the White Sox, and I appreciate a lot the opportunity they gave me to play in the big leagues," Escobar said. "But I appreciate being here, too. They've given me another opportunity here."
The addition of Escobar gives Minnesota four middle-infield options, along with Jamey Carroll, Alexi Casilla and Pedro Florimon. Gardenhire said he spoke with the four prior to Tuesday's game about how playing time will be split.
"We're going to play everybody, we're going to use everybody," Gardenhire said. "[They'll] take ground balls at each place out there and we'll just use combinations to make sure they all get a chance to play."