Willingham has been battling a sore hamstring and served as Minnesota's designated hitter the past two days after sitting out Sunday in Kansas City. Twins manger Ron Gardenhire said Willingham is mostly bothered by the injury when fielding in the outfield.
Gardenhire added he's hopeful the day off, as well Thursday's off-day, will give Willingham ample time to recover.
"If I can give him today and tomorrow, that would be a wonderful thing," said Gardenhire, adding Willingham would be available to pinch-hit. "He thinks he'll be able to get back out there and maybe play some outfield."
Among those in Wednesday's lineup was Eduardo Escobar, who played second and hit second after going 2-for-4 with three RBIs as the shortstop in Tuesday night's 18-9 win.
Escobar, who had a two-run single early in Tuesday's seven-run second, teamed with Pedro Florimon up the middle on Wednesday.
"It'll be entertaining to see them out there running around," Gardenhire said. "They're both very excitable young men and it'll be cool to see them out there."