The Twins rested first baseman Justin Morneau, center fielder Denard Span and designated hitter Ryan Doumit to give younger players a chance to play against Toronto.
Chris Parmelee got the start at first base, with Chris Herrmann starting in left field and Matt Carson in right field. Joe Mauer also started at DH, with Drew Butera at catcher.
"We want to get some guys in there a chance to get some swings," Twins manager Ron Gardenhire said. "We wanted to give guys like Morneau and Doumit a break. They've been playing every day. And Span. And let some of these kids have a chance. It's fun."