Bush, who has been solid this spring, lasted just two innings, giving up six runs on as many hits, including two home runs. Entering Sunday's game, he had a 2.45 ERA in 11 innings.
Dozier added a two-run shot in the second inning off Bush after Hicks doubled with one out. Hicks added a third hit on an RBI single in the fourth off Toronto reliever Jeremy Jeffress.
Jeffress then loaded the bases with nobody out, and Mauer came through with a three-run double off Rajai Davis' glove in left field. It gave Mauer six RBIs on the afternoon.
Morneau followed up with a two-run blast of his own off Blue Jays reliever Guillermo Moscoso. It was Morneau's third of the spring.
Butera got in on the action with a solo homer in the fifth inning, which came in a pinch-hit role, as he replaced Mauer.
Hicks, Dozier and Mauer combined to go 9-for-11 with two homers, two doubles, eight runs and nine RBIs. They gave the Twins all the offense they would need despite the fact that the Blue Jays had three homers of their own, including two from first baseman Luis Jimenez.
Right-hander P.J. Walters started for the Twins and went three-plus innings. He's a candidate for the starting rotation but might not be stretched out in time for the regular season.
Walters gave up three runs on four hits and two walks while needing 57 pitches to record 15 outs. He served up the two-run shot to Jimenez in the second inning before walking the first batter he faced in the fourth inning.
"I was all over the place with my location with a lot of guys," Walters said. "But at the same time we scored some runs. So if you have a bad day, that's the best time to do it."
Left-hander Brian Duensing came in to relieve Walters and promptly gave up Jimenez's second homer of the day. He later gave up a solo blast to Rajai Davis in the fifth inning.
Up next: Right-hander Mike Pelfrey is set to start for the Twins in a 1:05 p.m. ET game against the Cardinals at Hammond Stadium. Pelfrey, who had Tommy John surgery on May 1, has a 7.45 ERA in four outings this spring. Right-hander Shelby Miller is scheduled to take the mound for the Cardinals. Watch the game live on MLB.TV.
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, and follow him on Twitter @RhettBollinger. This story was not subject to the approval of Major League Baseball or its clubs.