Manager Ron Gardenhire said Arcia originally injured his wrist while taking swings in the cage before a game at U.S. Cellular Field earlier in the week. Arcia has started out the season slow offensively, going just 2-for-18 with a triple in four games.
Arcia dealt with a similar injury late last season and missed 12 out of 13 games in August as a result.
"He says he's fine to play through it," Gardenhire said. "He just has a little something in his hand. It's not worth it. The cold temperatures aren't helping right now."
Gardenhire added that he could see Arcia grimace in pain after taking swings in Friday's game against the Indians, and wanted to play it safe and take him out of the lineup on Saturday.
"I'm not going to watch a guy kill himself this early in the season," Gardenhire said. "We just can't keep doing this. We have to figure out what's wrong."
With Arcia out of the lineup, Jason Kubel made the start in right field and went 3-for-5 with two RBIs to help lead the Twins to a 7-3 win.
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, and follow him on Twitter @RhettBollinger. This story was not subject to the approval of Major League Baseball or its clubs.